Efferent modulation of hair cell function

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Efferent modulation of hair cell function.

PURPOSE OF REVIEW This review covers the articles published between 2010 and early 2011 that presented new findings on inner-ear efferents and their ability to modulate hair cell function. RECENT FINDINGS Studies published within the review period have increased our understanding of efferent mechanisms on hair cells in the cochlear and vestibular sensory epithelium and provide insights on eff...

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Efferent Control of Hair Cell and Afferent Responses

40 The sensations of sound and motion generated by the inner ear are controlled by the brain 41 through extensive centripetal innervation originating within the brainstem. In the semicircular 42 canals, brainstem efferent neurons make synaptic contacts with mechano-sensory hair cells and 43 with the dendrites of afferent neurons. Here, we examine the relative contributions of efferent 44 action...

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Evaluation of outer hair cell function and medial olivocochlear efferent system in patients with type II diabetes mellitus.

AIM This study was designed to investigate the function of outer hair cells and medial olivocochlear efferents in type II diabetes mellitus (DM). MATERIALS AND METHODS There were 50 patients with type II DM and 51 age- and sex-matched healthy controls included in the study. Both groups were compared in terms of transient evoked otoacoustic emissions (TEOAEs), distortion product otoacoustic em...

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Onset of cholinergic efferent synaptic function in sensory hair cells of the rat cochlea.

In the developing mammalian cochlea, the sensory hair cells receive efferent innervation originating in the superior olivary complex. This input is mediated by α9/α10 nicotinic acetylcholine receptors (nAChRs) and is inhibitory due to the subsequent activation of calcium-dependent SK2 potassium channels. We examined the acquisition of this cholinergic efferent input using whole-cell voltage-cla...

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Role of Nicotinic Acetylcholine Receptor on Efferent Inhibition in Cochlear Hair Cell

The α9α10 nicotinic acetylcholine receptors (nAChRs) mediates efferent inhibition of hair cell function within the auditory sensory organ. Gating of the nAChRs leads to activation of calcium-dependent potassium channels to hyperpolarize the hair cell. In efferent system, main calcium providers to SK channel are nAChR and synaptic cistern, which contribution to efferent inhibition is different b...

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ژورنال

عنوان ژورنال: Current Opinion in Otolaryngology & Head & Neck Surgery

سال: 2011

ISSN: 1068-9508

DOI: 10.1097/moo.0b013e32834a5be1